File:Computational-Simulation-of-the-Activation-Cycle-of-Gα-Subunit-in-the-G-Protein-Cycle-Using-an-pone.0159528.s011.ogv
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DescriptionComputational-Simulation-of-the-Activation-Cycle-of-Gα-Subunit-in-the-G-Protein-Cycle-Using-an-pone.0159528.s011.ogv |
English: Animation showing the hypothesized conformational changes of the G protein throughout the G protein cycle. The GDP-bound heterotrimer (gray) binds to activated receptor (blue), and the nucleotide-binding pocket region consisting of β6-α5, the P-loop and switch 2 are perturbation, resulting in GDP (purple) release. Subsequently, the helical domain of Gα(GDP) opens away from the receptor-anchored Ras domain, which allows GDP release and GTP (orange) to enter. Reorientation of Gα caused by GTP binding leads to dissociation of the receptor and Gβγ (Gβ; green and Gγ; cyan). GTP hydrolysis leads to rebinding of Gβγ to Gα in order to restart the G protein signaling cycle. |
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Source | S1 Video from Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M (2016). "Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model". PLOS ONE. DOI:10.1371/journal.pone.0159528. PMID 27483005. PMC: 4970668. | ||
Author | Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 20:38, 26 August 2016 | 17 s, 1,920 × 1,080 (7.84 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Animation showing the hypothesized conformational changes of the G protein throughout the G protein cycle. |
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Author | Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M |
Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | The GDP-bound heterotrimer (gray) binds to activated receptor (blue), and the nucleotide-binding pocket region consisting of β6-α5, the P-loop and switch 2 are perturbation, resulting in GDP (purple) release. Subsequently, the helical domain of Gα(GDP) opens away from the receptor-anchored Ras domain, which allows GDP release and GTP (orange) to enter. Reorientation of Gα caused by GTP binding leads to dissociation of the receptor and Gβγ (Gβ; green and Gγ; cyan). GTP hydrolysis leads to rebinding of Gβγ to Gα in order to restart the G protein signaling cycle. |
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Date and time of digitizing | 2016-08-02 |
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2 August 2016
application/ogg
eec6837404a94d490e94f135505a3d7775c8d2a3
8,220,859 byte
16.708333333333332 second
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1,920 pixel
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