File:A-Mathematical-Model-for-Neutrophil-Gradient-Sensing-and-Polarization-pcbi.0030036.sv001.ogv
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A-Mathematical-Model-for-Neutrophil-Gradient-Sensing-and-Polarization-pcbi.0030036.sv001.ogv (Ogg Theora video file, length 0.0 s, 432 × 336 pixels, 0 bps, file size: 2.28 MB)
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DescriptionA-Mathematical-Model-for-Neutrophil-Gradient-Sensing-and-Polarization-pcbi.0030036.sv001.ogv |
English: Separation of PI3K and RhoA in Response to a 50% Gradient of Chemoattractant The abscissa is the location of cell periphery and the ordinate is dimensionless concentration. Application of chemoattractant gradient first causes localization of the receptor–ligand complexes (black dashed line), and then as active PI3K (red line) localizes to the front, RhoA (blue line) disassociates from the front and localizes to the rear where active PI3K levels are low. After the molecules have reached their spatial steady state, the gradient direction is reversed and the front and back reform, indicating there is no “lock-on” behavior. |
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Source | Video S1 from Onsum M, Rao C (2007). "A Mathematical Model for Neutrophil Gradient Sensing and Polarization". PLOS Computational Biology. DOI:10.1371/journal.pcbi.0030036. PMID 17367201. PMC: 1828701. | ||
Author | Onsum M, Rao C | ||
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current | 03:27, 31 October 2012 | 0.0 s, 432 × 336 (2.28 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Separation of PI3K and RhoA in Response to a 50% Gradient of Chemoattractant |
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Author | Onsum M, Rao C |
Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | The abscissa is the location of cell periphery and the ordinate is dimensionless concentration. Application of chemoattractant gradient first causes localization of the receptor?ligand complexes (black dashed line), and then as active PI3K (red line) localizes to the front, RhoA (blue line) disassociates from the front and localizes to the rear where active PI3K levels are low. After the molecules have reached their spatial steady state, the gradient direction is reversed and the front and back reform, indicating there is no ?lock-on? behavior. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2007-03 |