File:Aves Cells in EMT trigger a chain reaction of EMT in a Nodal-dependent manner.jpg

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Fig 5. Cells in EMT trigger a chain reaction of EMT in a Nodal-dependent manner.

(A) EMT cells from the early PS of a quail embryo (left) are grafted under the epiblast of a pre-PS chick embryo (right). (B) Grafted cells (brown stain, thin black arrow) upregulate EMT markers (cSnail2, purple) and trigger EMT from the epiblast above, after 4 hr. (C) Grafted embryo after 15 hr. The grafted quail cells (brown) have migrated away, and the new PS they triggered (‘2o PS’) is composed of host cells. The PS developing along the original orientation is labelled ‘1o PS’. In grafts combined with COS cells secreting Cerberus (E) or Cer-S (F), or beads soaked in SB431542 (H) or SB505124 (I), EMT (thickening) from the epiblast and induction of cSnail2 (purple) in the epiblast (red arrows) are abolished. Control COS cells (D) or beads soaked in DMSO (G) do not abolish the induction by the grafted mesoderm (black arrows). Mesoderm from a region lateral to the PS cannot induce EMT or cSnail2 either alone (not shown) or in the presence of GFP-transfected COS cells (J) or beads soaked in solvent alone (K) (red arrows).
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Source https://doi.org/10.7554/eLife.01817 Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation eLife 3:e01817.
Author Octavian Voiculescu Lawrence Bodenstein I-Jun Lau Claudio D Stern
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© 2014, Voiculescu et al.

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current20:58, 16 April 2024Thumbnail for version as of 20:58, 16 April 2024976 × 1,500 (322 KB)Rasbak (talk | contribs){{Information |description=Fig 5. Cells in EMT trigger a chain reaction of EMT in a Nodal-dependent manner.<br> (A) EMT cells from the early PS of a quail embryo (left) are grafted under the epiblast of a pre-PS chick embryo (right). (B) Grafted cells (brown stain, thin black arrow) upregulate EMT markers (cSnail2, purple) and trigger EMT from the epiblast above, after 4 hr. (C) Grafted embryo after 15 hr. The grafted quail cells (brown) have migrated away, and the new PS they triggered (‘2o...

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